Multifocal Neurologic Manifestation of Coronavirus Disease 2019 Infection: Report of 2 Cases




COVID-19, SARS-COV-2, Polyneuropathies, Neuropathy, Guillain-Barre syndrome, Myelitis


Background: The most common neurological symptoms of coronavirus disease 2019 (COVID-19) were hypogeusia and hyposmia; neuropathy was recently reported in patients with COVID-19. It is not yet clear if the virus has the potential to affect the nervous system or it is just a co-incidental finding. In this study, we report 2 patients with a history of COVID-19 presenting neurological symptoms and weakness, who did not meet the Guillain‐Barre syndrome (GBS) criteria.

Case Report: The first patient was a 56-year-old man who developed flu-like symptoms and was isolated for fourteen days after being diagnosed with COVID-19 through positive polymerase chain reaction (PCR) test and lung computed tomography (CT) scan. Three weeks later, the patient developed right-sided peripheral facial palsy, four-limb paresthesia, and progressive lower limb weakness. The second patient was a 62-year-old man with more or less the same presentation as patient number 1 except for lack of facial involvement and normal lower limbs’ sensory nerve conduction study (NCS).

Conclusion: Here, we have reported 2 cases that developed neuropathic symptoms following the COVID-19 symptoms in the recovery period. The majority of the research regarding neuropathies in patients with COVID-19 studied the facial nerve involvement and GBS, and a sensory-predominant polyneuropathy is not yet reported, as far as we know. With the suspicion of an acute myelitis and sensory neuropathy, the patients were prescribed intravenous immunoglobulin (IVIg).



How to Cite

Rayegani, S. M. ., Jalalian, B. ., Babaee, M. ., & Hojjati, F. . (2020). Multifocal Neurologic Manifestation of Coronavirus Disease 2019 Infection: Report of 2 Cases. JPMRE, 2(1), 32–34.



Case Report(s)